IL18R1 and early-onset autosomal dominant Alzheimer disease: The analysis of the 31 statistically significant DEGs from the GSE99039 database revealed, as expected, the regulation of several broad inflammatory pathways, including “Th1, Th2, and Th17 differentiation”, “JAK-STAT signaling”, and “cytokine–cytokine receptor interaction.” Interestingly, we also observed enrichment in pathways typically associated with nervous tissue—such as “neurodegeneration”, “Alzheimer’s disease”, and “neuroactive ligand–receptor interaction”—within leukocytes.