By matching the HLA-DRB1 and DQB1 alleles with the Expanded Disability Scale Status (EDSS) score of the disease, indicating the severity degree of disability during MS course, we noticed that DQB1*06:02, DRB1*15:01, DRB1*13:01, and alleles were associated with higher disability trends, with the mean EDSS scores estimated at 6, 5.8, and 5 respectively. The gene discussed is HLA-DRB1; the disease is myeloid sarcoma.