Furthermore, we analyzed the association of HLA alleles with MS subtypes (RRMS, SPMS, and PPMS) and EDSS score to assess their influence on MS progression, which showed that HLA–DRB1*03:01 was the most frequent allele in RRMS patients (33.6%) with moderate disability (EDSS = 3.4), followed by DRB1*15:01, seen in 11% among the same group with higher disability trend (EDSS = 5); although these alleles appeared more common in certain subtypes or EDSS ranges, these trends were not statistically significant and must be interpreted as exploratory until validated in larger, independent cohorts. The gene discussed is HLA-DRB1; the disease is myeloid sarcoma.