The data of the current study highlighted a high frequency of DRB1*03:01, DRB1*15:01, DRB1*04:01, and DQB1*03:19 HLA alleles, along with DRB1*15:01-DQB1*06:02 association, which are linked with a possible trend of association with the risk of MS within the population of southern Morocco. This evidence concerns the gene HLA-DRB1 and myeloid sarcoma.