Furthermore, in a human ALS-linked mutant superoxide dismutase-1 (SOD1G93A) transgenic mouse model of ALS (G93A mice), suppression of microglial/macrophage proliferation apparently contributes to the neuroprotective effects of MBP on motor neurons in the lumbar spinal cord [14]. The gene discussed is MBP; the disease is amyotrophic lateral sclerosis.