Parallel studies have reported that the knockdown of TDP-43 in human neuroblastoma cell lines decreases Dicer and TBPH physically interact with DCR-2 mRNA and its protein product [31], suggesting that TDP-43/TBPH is essential for the transport of the RISC inside or outside the nucleus or may contributes to the binding and recognition of RNA targets. The gene discussed is TARDBP; the disease is neuroblastoma.