APP and dementia: Since most of the identified proteins are not present in both diseases, we performed two independent PPI analyses: the first using the proteins associated with HF (NPPB, REN, ADIPOQ, VWF, ACE, IL6, and CRP) and the second using the proteins involved in dementia (CRP, APP, MAPT, APOE, ACE, and IL6) (Figure 4).