Administration of C. lanatus, particularly at the highest dose (P3 = 1000 mg/day/rat), significantly improved lipid profiles (decreasing total cholesterol, triglycerides, LDL, and increasing HDL), reduced oxidative stress (ROS) and inflammation (TNF-α), and attenuated histopathological markers of atherosclerosis, including foam cell formation and tunica intima thickness. The gene discussed is TNF; the disease is atherosclerosis.