The potential ROS scavenging effect and the hyaluronidase resistance offered protection of colonic epithelial cells, after DSS induced colitis (in C57BL/6 mice after oral delayed treatment), with preservation of the colon length and body weight and reduction in the colonic damage and the MPO activity (with parallel improvement of the inflammatory IL-1β and TNF-α, and of the anti-inflammatory ΙL-10 and tumor growth factor β markers). The gene discussed is MPO; the disease is colitis.