Overall, the results highlight, confirm, and underscore the role of OPCML’s regulation of RTK signaling and the downstream signaling pathways of PI3K/AKT and MEK/ERK, and also identify three new potential RTK linkages to KIT, TEK, and potentially ROS1 in ovarian cancers in the context of OPCML regulation. This evidence concerns the gene ROS1 and ovarian carcinoma.