Overall, the results highlight, confirm, and underscore the role of OPCML’s regulation of RTK signaling and the downstream signaling pathways of PI3K/AKT and MEK/ERK, and also identify three new potential RTK linkages to KIT, TEK, and potentially ROS1 in ovarian cancers in the context of OPCML regulation. The gene discussed is AKT1; the disease is ovarian carcinoma.