TP53 and neoplasm: Their tumor-modulating activities primarily stem from the ubiquitination-mediated regulation of cancer-associated substrates, particularly those governing fundamental oncogenic processes such as cell cycle control; DNA repair mechanisms; EMT regulation; and key signaling cascades such as the PI3K/AKT, BMP, p53, NRF2, AMPK/mTOR, NF-κB, and Hippo pathways.