When the expression of PGC-1α and its downstream target genes TFAM, NRF1/2 is suppressed, it affects the replication and transcription of mtDNA, leading to impaired mitochondrial biogenesis, which induces mitochondrial dysfunction and further triggers energy metabolism disorders and oxidative stress, mediating the onset of depression [32]. The gene discussed is PPARGC1A; the disease is depressive disorder.