While previous research has elucidated some mechanisms of quercetin, kaempferol, isorhamnetin, and calycosin in the context of AP, our study identifies previously unreported potential mechanisms involving TP53, AKT1, EGFR, CASP3, MYC, and HIF1A and their associated signaling pathways. The gene discussed is EGFR; the disease is alkaline phosphatase measurement.