Key active ingredients, such as quercetin, kaempferol, isorhamnetin, formononetin, and calycosin, interact with core targets, including TP53, AKT1, TNF, IL6, EGFR, CASP3, MYC, and HIF1A, within primary pathways like Pathways in cancer, Lipid metabolism and atherosclerosis, and the PI3K-Akt signaling pathway. The gene discussed is MYC; the disease is atherosclerosis.