Any studies have shown significant differential miRNA expression profiles in breast cancer tissues compared to those of non-cancerous tissue, Subsequent investigations demonstrated that the genetic alteration of miR-155-5p greatly influenced the cell response to paclitaxel by modulating TP53INP1 expression miR-155-5p was overexpressed and TP53INP1 was down-regulated in MCF-7/PR compared with MCF-7 cells. This evidence concerns the gene TP53INP1 and breast cancer.