The aforementioned study demonstrates that exercise-induced DA exhibits dual regulatory effects in cancer modulation: moderate exercise intervention elevates DA levels, which inhibit LC metastasis and BC proliferation through suppression of the PI3K/Akt pathway and VPF/VEGF signaling; conversely, excessive physical activity may paradoxically promote tumor progression. The gene discussed is VEGFA; the disease is laryngotracheoesophageal cleft.