TGF-β has been shown to act in a context-dependent manner in many conditions; for example, in tumor progression, it acts as a tumor promoter, enhancing cell expansion and migration to metastasize, as it undergoes mutation and epigenetic modulation to become deactivated with no usual suppressive effect on cancer cells [32,33,34,35,36,37,38]. Here, TGFB1 is linked to neoplasm.