Tirzepatide, a dual GLP-1/GIP receptor agonist, amplifies these effects through synergistic receptor activation, demonstrating 12.9 kg average weight loss in SURPASS trials whilst improving hepatic inflammation markers in patients with obesity-related non-alcoholic steatohepatitis (NASH) [61,62]. The gene discussed is GLP1R; the disease is obesity due to melanocortin 4 receptor deficiency.