PTK2 and prostate cancer: Furthermore, ανβ3-integrin is one of the most studied adhesion molecules in prostate cancer, having been reported as essential for extracellular matrix adhesion during invasion and metastasis [93], and not only interacts with the actin cytoskeleton and the related scaffold proteins, but also regulates survival and drives metastasis-related genes by clustering and acting as recruitment areas where phosphorylation of FAK can take place.