A systematic review of 45 studies highlighted how full-length L1CAM (L1CAM-FL) and its cleaved forms could be identified in various cellular environments and influence cancer cell behavior through different signaling pathways, such as integrins, FAK/Src, PI3K/Akt, FGFR, Ezrin, ERK, NF-κB, and L1CAM-FL. This evidence concerns the gene L1CAM and cancer.