In acute MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced PD models, astrocytic conversion to MPP (mitochondrial-processing peptidase)-positive states facilitate dopaminergic neuron uptake, followed by microglial CX3CR1-mediated calcium flux and activation of NLRP3 inflammasome—events that precede dopaminergic neuronal loss [118,119] (Figure 4A). This evidence concerns the gene NLRP3 and Parkinson disease.