For allergy, the main pathways included AGE-RAGE signaling pathway in diabetic complications, EGFR tyrosine kinase inhibitor resistance, PD-L1 expression and PD-1 checkpoint pathway in cancer, prostate cancer, TH17 cell differentiation, lipid and atherosclerosis, hepatitis B, Kaposi sarcoma-associated herpesvirus infection, neuroactive ligand-receptor interaction, and pathways in cancer (Figure 4B). The gene discussed is CD274; the disease is atherosclerosis.