Here, we characterized the gpx4 gene in blunt snout bream, examined its expression patterns under different conditions, and measured ferroptosis markers such as MDA levels, the ratio of GSH to oxidized glutathione (GSSG), and reactive oxygen species (ROS) in cell models with gpx4 overexpression after ferroptosis induction/bacterial infection in vivo. This evidence concerns the gene GPX4 and bacterial infectious disease.