Key components such as Quercetin, Kaempferol, Nuciferine, and O-nornuciferine interacted significantly with targets such as NF-κB, PPAR, IL-10, TP53, and Caspase-3, suggesting that these are critical targets for lotus leaf in combating inflammatory diarrhea. The gene discussed is NFKB1; the disease is inflammatory diarrhea.