NECTIN4 and neoplasm: They found that membranous Nectin-4 expression was seen in 30.3% of cases of primary tumors and 55.0% of cases of lymph node metastases, while cytoplasmatic expression comprised 77.0% of primary tumors and 80.0% of lymph node metastases, confirming correlations between Nectin-4 expression and histopathological features like high tumor grade, lymph node metastasis, and advanced stage of tumor development [60].