The objective of this pilot study was to investigate and evaluate the expression of Nectin-2 and Nectin-4 in LSCC using tissue microarrays (TMAs) and immunohistochemistry (IHC) and to provide a more comprehensive understanding of their role in tumor biology, their aggressiveness and metastatic behavior, and the overall prognostic value of these molecules. The gene discussed is NECTIN4; the disease is neoplasm.