NECTIN4 and cancer: Extensive research has demonstrated the overexpression of Nectin-4 across a variety of malignant tumors, including breast cancer [24,25], ovarian carcinoma [26], hepatocellular carcinoma [27], gastric cancer [28], pancreatic cancer [29], bladder cancer [30,31,32], cutaneous squamous cell carcinoma [33,34], esophageal cancer [35], and salivary gland cancer [36].