-rs3765467 GG genotype associated with greater HbA1c reduction and treatment response in Chinese T2DM patients [22].-rs10305420 T allele homozygosity linked to better glycemic response to liraglutide in Iranian T2DM patients [134].-rs6923761 showed no association with HbA1c reduction [22].-rs3765467 and rs10305492 linked to impaired insulin secretion and β cell apoptosis [135].(The exact mechanism by which these two SNPs can influence insulin secretion following GLP-1RA treatment in T2DM still not established.) Here, INS is linked to type 2 diabetes mellitus.