GLP-1 receptors exhibit widespread expression in critical regions of the CNS, including areas involved in mood regulation, anxiety, reward processing, and cognition, notably like the hippocampus, amygdala, prefrontal cortex, hypothalamus, ventral tegmental area (VTA), nucleus accumbens (NAc), and nucleus tractus solitarius (NTS) [112,113]. This evidence concerns the gene GLP1R and Anxiety.