INS and obesity due to melanocortin 4 receptor deficiency: Other miRNAs, including hsa-miR-519b-3p, hsa-miR-384, hsa-miR-488-3p, and hsa-miR-877-3p, target the key molecules involved in glucose metabolism, insulin resistance, and adipose tissue differentiation, reinforcing their role in obesity pathophysiology [71,72,73].