A recent study found that arsenic exposure can lead to IL-8 overexpression via the phosphorylation of human epidermal growth factor receptor 2 (HER2), promoting migration and EMT while activating ERK (extracellular signal-regulated kinase), AKT, and STAT3 (signal transducer and activator of transcription 3) signaling pathways to increase cancer stem cell markers such as CD44 in bladder epithelial cells. The gene discussed is STAT3; the disease is cancer.