Wang et al. found that the PI3K/Akt signaling pathway in diabetic mice is inhibited compared to normal mice, and the activation of this pathway is often accompanied by a reduction in insulin resistance, which improves insulin resistance and affirms the important role of PI3K/Akt in regulating glucose metabolism in type 2 diabetes (T2DM). This evidence concerns the gene AKT1 and type 2 diabetes mellitus.