KDM4C and colorectal carcinoma: Pu et al. showed that another circular RNA, circ_0000345, promoted CRC lung metastasis by enhancing the activation of the KDM4C/β-catenin signaling pathway through miR-205-5p, whereas a natural flavonoid compound, kaempferol, inhibited KDM4C/β-catenin signaling by decreasing circ_0000345 expression and suppressing CRC metastasis [30].