Zhang et al. demonstrated that KDM1A upregulated tetraspanin 8 expression to promote CRC cell proliferation and migration by decreasing H3K9me2 occupancy at the tetraspanin 8 promoter, whereas tetraspanin 8 promoted EMT in a KDM1A-dependent manner [99]. Here, TSPAN8 is linked to colorectal carcinoma.