RHOA and colorectal carcinoma: KDM2B knockdown induced upregulation of protein levels of epithelial markers E-cadherin and zonula occludens-1 but downregulation of protein levels of mesenchymal markers N-cadherin and three small GTPases (RhoA, RhoB, and RhoC), suggesting that KDM2B may be involved in the EMT, cytoskeletal rearrangement, and migratory capacity of CRC cells [108].