KDM5B and colorectal carcinoma: Yan et al. found that KDM5B reduced CC chemokine ligand 14 expression through demethylation of H3K4me3 to activate Wnt/β-catenin, and that KDM5B knockdown or overexpression of CC chemokine ligand 14 inhibited the proliferation and invasiveness of CRC cells [151].