Jin et al. found that KDM1A deletion (KDM1A heterozygous and homozygous knockout) in the HCT116 cell line significantly inhibited CRC cell proliferation in vitro and in vivo but did not lead to changes in H3K4me2 and H3K9me2 at the global cellular level and did not affect the protein levels or function of p53 or DNA methyltransferase I [83]. Here, TP53 is linked to colorectal carcinoma.