In addition, AMPK signaling pathway, VEGF/VEGFR signaling pathway, HGF/cMET signaling pathway, immune checkpoint signaling pathway, RHOA signaling pathway, ErbB signaling pathway, Nrf2/Keap1 signaling pathway and NF-κB signaling pathway may also be involved in the tumorigenesis and progression of CRC [33,60]. This evidence concerns the gene RHOA and colorectal carcinoma.