KDM4B and colorectal carcinoma: Liu et al. showed that enterotoxigenic Bacteroides fragilis increased stemness of CRC cells both in vivo and in vitro by upregulating KDM4B levels via the Toll-like receptor 4-nuclear factor of activated T cells 5-dependent pathway, which was mediated by upregulation of Nanog homeobox expression by KDM4B (via H3K9me3 demethylation on the promoter) [136].