Lin et al. found that KDM5C overexpression significantly reduced the half maximal inhibitory concentrations (IC50) of oxaliplatin and irinotecan and promoted multidrug resistance in CRC by reducing ATP Binding Cassette Subfamily C Member 1 expression through H3K4me3 demethylation at the transcriptional start site of ATP Binding Cassette Subfamily C Member 1 [152]. This evidence concerns the gene KDM5C and colorectal carcinoma.