Cao et al. reported for the first time that the expression level of KDM2A was elevated in human colorectal adenocarcinoma tissues by immunohistochemical assay, and further investigation revealed that KDM2A promoted colorectal adenocarcinoma cell proliferation and colony formation and was closely related to the expression of cyclin D1 [103]. This evidence concerns the gene CCND1 and colorectal adenocarcinoma.