Fu et al. showed that KDM4B was overexpressed in CRC cells in a hypoxia-inducible factor 1α-dependent manner under hypoxia and regulated CRC biological behaviors by upregulating the expression of a subset of hypoxia-inducible genes through demethylation of H3K9me3 [128]. The gene discussed is KDM4B; the disease is colorectal carcinoma.