Liu et al. showed that phosphatase of regenerating liver 3, a key metastatic gene in CRC, affected the activity of KDM3B and KDM4B as a key regulator of histone demethylation, and that the low expression of KDM3B was positively correlated with the lymph node status, Dukes classification, and TNM stage of CRC patients [124]. This evidence concerns the gene KDM3B and colorectal carcinoma.