KDM5A and colorectal carcinoma: Evensen et al. found that hypoxia-inducible factor 2α directly binds to hypoxia-responsive elements within the promoter region of cell migration-inducing protein, thereby inhibiting KDM5A function, leading to increased levels of H3K4me3 within the cell migration-inducing protein promoter and upregulation of cell migration-inducing protein, which drives CRC cell EMT and migration [146].