Ding et al. showed that the long noncoding RNA (lnc RNA) HOXA-AS2 could bind to KDM1A and EZH2 (enhancer of zeste homolog 2, an HMT) and recruit them to the promoter regions of p21 (a cell cycle inhibitor) and Krüppel-like factor 2 (a tumor suppressor), thereby repressing the transcription of these genes [90], while Tian et al. showed that another lncRNA, FEZF1-AS1, also modulated CRC cell growth by interacting with KDM1A and inhibiting Krüppel-like factor 2 expression [91]. The gene discussed is EZH2; the disease is colorectal carcinoma.