Liu et al. observed that lncRNA LINC00586 recruited KDM1A to the ASXL1 (a tumor suppressor) promoter region and epigenetically silenced ASXL1 expression, and that INC00586 knockdown inhibited HCT116 and LoVo cell viability, migration, and EMT as well as tumorigenesis in nude mice xenografted with HCT116 cells [93]. The gene discussed is ASXL1; the disease is neoplasm.