KDM4D and colorectal carcinoma: Zhuo et al. demonstrated that KDM4D interacts with Gli2 to reduce the level of H3K9me3 at the promoter and thus promotes the expression of Hedgehog pathway target genes, and that KDM4D inhibitors work synergistically with Hedgehog pathway inhibitors to inhibit CRC cell proliferation and tumorigenesis [145].