CD274 and colorectal carcinoma: Liao et al. showed that ARID3B (AT-rich interaction domain-containing protein 3B) recruited KDM4C for H3K9me3 demethylation to activate Notch target genes, intestinal stem cell genes, and programmed death ligand 1 (PD-L1) to promote stem cell-like properties and immune escape in CRC cells [140].