PIK3CA and colorectal carcinoma: Dysregulation of signaling cascade responses has an important mediating role in CRC pathogenesis, including, but not limited to, the Wnt/β-catenin signaling pathway, RAS/MAPK signaling pathway, PI3K/AKT/mTOR signaling pathway, JAK/STAT signaling pathway, TGF-β/Smad signaling pathway, Notch signaling pathway, Hippo signaling pathway, and Hedgehog signaling pathway [33,42,43].