Chen et al. found that RNA N6-adenosylmethyltransferase methyltransferase-like 14 inhibited CRC progression through SRY-Box Transcription Factor 4-mediated EMT and PI3K/Akt signaling, whereas KDM5C inhibited methyltransferase-like 14 transcription through H3K4me3 demethylation at the methyltransferase-like 14 promoter [153]. The gene discussed is PIK3CA; the disease is colorectal carcinoma.