KDM4B and colorectal carcinoma: Li et al. consistently showed that KDM4B inhibition significantly promoted mitochondrial apoptosis in CRC cells, and that these effects were induced partly by transcriptional repression of HCLS1 associated protein X-1 (an anti-apoptotic gene) through demethylation of H3K9me3 in the HCLS1 associated protein X-1 promoter region [135].