Consistently, Peng et al. reported that KDM3A demethylated H3K9me2 at c-Myc and matrix metalloproteinase 9 promoters and enhanced Wnt/β-catenin signaling by promoting β-catenin expression and interacting with β-catenin to enhance its transactivation to promote CRC progression [115]. The gene discussed is KDM3A; the disease is colorectal carcinoma.