KDM6B and malignant colon neoplasm: Pereira et al. found that the vitamin D metabolite 1,25(OH)2D3 induced KDM6B expression in colon cancer cells in a vitamin D receptor-dependent manner, whereas knockdown of KDM6B attenuated the inhibitory effects of 1,25(OH)2D3 on the Wnt/β-catenin signaling pathway and led to increased expression of the EMT markers [166].