KDM4B and colorectal carcinoma: Tan et al. further showed that depletion of KDM4B under glucose deficiency inhibited autophagy in CRC cells through H3K9me3 demethylation of the light chain 3 beta promoter, which reduced intracellular levels of specific amino acids (asparagine, phenylalanine, and histidine) and thus inhibited CRC cell survival [133].