TP53 and colorectal carcinoma: Mechanistic studies showed that KDM1B promoted CRC cell proliferation by directly binding to the p53 promoter region and inhibiting p53 expression through H3K4me2 demethylation, which in turn inhibited the p53-p21-Rb pathway to regulate cell cycle progression (especially the G1/S phase transition) and inhibit apoptosis [25].