CD3+ CD8+ CD57+ T large granular lymphocyte lymphoproliferative disorders (T-LGL LPD) may be either idiopathic or develop in the context of viral infections, autoimmune disorders, after organ transplantation or allogeneic hematopoietic cell transplantation, as well as in patients after receiving anti-CD20 monoclonal antibody for the treatment of B lymphoma [4,5,6,7,8,9,10,11,12]. The gene discussed is B3GAT1; the disease is Autoimmunity.