CD3+ CD8+ CD57+ T large granular lymphocyte lymphoproliferative disorders (T-LGL LPD) may be either idiopathic or develop in the context of viral infections, autoimmune disorders, after organ transplantation or allogeneic hematopoietic cell transplantation, as well as in patients after receiving anti-CD20 monoclonal antibody for the treatment of B lymphoma [4,5,6,7,8,9,10,11,12]. Here, CD8A is linked to viral infectious disease.