The hematopoietic failure in CIN appears to be mainly due to Fas-antigen-expression-induced apoptosis of CD34+/CD33+ hematopoietic progenitors and secondarily to increased concentrations of pro-inflammatory and pro-apoptotic cytokines of macrophage stromal origin in bone marrow. The gene discussed is FAS; the disease is cervical squamous intraepithelial neoplasia.