Moreover, recent research data further highlighted the major role that might be played by molecules, such as TNF-α and IFN-γ, and by overproduction in LGLs, which can activate the Fas-L pathway and increase the generation of reactive oxygen species (ROS), which can directly harm the BM microenvironment and exacerbate neutropenia [99]. Here, TNF is linked to Decreased total neutrophil count.