GDF6 and cancer: GDF6 was significantly positively correlated with HRD in six types of cancer, such as LUAD, ESCA, KIRP, PRAD, HNSC, and OV, and significantly negatively correlated in three types of cancer, such as BRCA, KIRC, and TGCT, suggesting that it may affect homologous recombination repair efficiency through tissue-specific mechanisms (Figure 5E).