Although these observations provide further evidence that SOX7 is, probably, the most likely candidate gene deserving further investigation in del8p23.1 as a tumor suppressor, we cannot exclude the possibility that PINX1 or MSRA may also have tumor suppressor role owing to their downregulation through deletion and/or promoter methylation in MM cases (Figure 5). Here, PINX1 is linked to Miyoshi myopathy.