The results showed that serum albumin (Alb), transforming growth factor-β (Tgfb1), intercellular cell adhesion molecule-1 (Icam-1), cluster of differentiation 4 (Cd4), receptor tyrosine phosphatase type C (Ptprc), integrin beta-1 (Itgb1), collagen type I alpha-1 (Col1a1), peroxidasin (Pxdn), and integrin alpha-D (Itgad) were jointly identified as key pivotal genes in all three algorithms, suggesting that they may play a central role in migraine pathology. This evidence concerns the gene ICAM1 and migraine disorder.