PXDN and migraine disorder: In this study, we identified that NTG-induced migraine is associated with the PI3K–Akt signaling pathway, cytokines and their receptor interactions, and nine key hub genes (Alb, Tgfb1, Cd4, Ptprc, Itgb1, Icam1, Col1a1, Pxdn, and Itgad) through transcriptomics.