Dysregulation of the ECS has been implicated as a contributing factor in this condition, with evidence pointing to altered levels of endocannabinoids or reduced function of CB1R and CB2R. Such disruptions could destabilize the natural ability to modulate pain and preserve homeostasis; as a result, this phenomenon could amplify pain sensitivity and intensify other symptoms typical of fibromyalgia. The gene discussed is CNR1; the disease is fibromyalgia.