Future validation efforts should focus on protein-level confirmation of both classical key senescence regulators such as p16INK4A, p21Cip1, p15INK4b, and γH2Ax [71,72,73] and some of the targets identified in this work (e.g., SASP factor MMP10) or by others (e.g., SASP factor MMP7) in matched colorectal adenomas and carcinomas [68]. This evidence concerns the gene CDKN1A and carcinoma.