IGHE and anaphylaxis: Immunologic anaphylaxis can be further subcategorized into immunoglobulin E (IgE)-mediated (e.g., food, drugs, and insect stings) and IgE-independent forms, which include immunoglobulin G (IgG)-dependent anaphylaxis (e.g., high molecular weight iron dextran, and infusion of human mAbs, such as infliximab), and complement-mediated (e.g., oversulfated chondroitin sulfate-contaminated heparin and polyethylene glycols) [2].