DLL3 and large cell neuroendocrine carcinoma: Small-cell (n = 1) lung carcinoma expressed DLL3 moderately, and large-cell neuroendocrine carcinomas (n = 2) of the lung demonstrated strong DLL3 positivity (50–90% of cells; average H-score 180 combined, range 120 to 270) in all the tumors examined, including metastatic foci (Fig. 5).