18F-FDG uptake is closely associated with several key tumor processes, including glucose metabolism (mediated by GLUT1 and hexokinase I), hypoxia response (via HIF-1α), angiogenesis (driven by VEGF and CD34), and the PI3K/Akt/mTOR signaling pathway, which promotes tumor invasiveness [31]. The gene discussed is AKT1; the disease is neoplasm.