HBV integration frequently targets cancer-associated genes like human telomerase gene (TERT), the lysin methyltransferase 2B (KMT2B), cyclin E1 (CCNE1), and cyclin A2 (CCNA2), fragile genomic sites, and repetitive sequences, enhancing HCC risk (26, 27, 33, –, 37). The gene discussed is CCNE1; the disease is hepatocellular carcinoma.