RHOA and breast cancer: Among these candidate proteins, Nedd9 (aka HEF-1 or Cas-L) caught our interest as it was previously reported in breast cancer cells to localize to the cleavage furrow during cytokinesis where it activates RhoA, as well as abnormal expression of Nedd9 results in cytokinesis defect (Dadke et al., 2006; Zhang and Wu, 2015; Zhong et al., 2012; Figure 4A-B).