The recognition functions of AS1411 or anti-MUC-1aptamer toward nucleolin or MUC-1 receptors associated with MDA-MB-231breast cancer cells favored the localization of the Ce4+-C-dots to the cancer cells, thereby catalyzing the generation ofROS agents for the targeted chemodynamic treatment of MDA-MB-231 breastcancer cells and tumors. The gene discussed is NUCLEOLIN; the disease is cancer.