GLA and Fabry disease: Another prominent example is Fabry's disease, a monogenic lysosomal storage disorder caused by mutations in the alpha‐galactosidase A (GLA) gene [475], which in humans relates to severe podocyte injury in part through alpha‐synuclein accumulation [476] and notch1‐mediated inflammatory and fibrogenic responses [477], but in mice does not affect podocyte biology significantly [478].