Long-term activation of GLP-1receptors was observed to stimulate calcitonin secretion and induceC-cell hyperplasia, leading to a higher incidence of medullary thyroidcancer in mice. However, in human studies,liraglutide did not significantly affect calcitonin secretion. As a result, the potential correlation betweenGLP-1RAs and thyroid cancer remains unclear. This evidence concerns the gene CALCA and thyroid gland carcinoma.