Yet the consequences are not merely skin-deep. IL-17A and other cytokines also provoke endothelial dysfunction and vascular activation, directly linking psoriasis to atherosclerosis and cardiovascular risk [12]. This systemic inflammatory profile is amplified because IL-17A is also produced outside of skin plaques by various cells, including dendritic, natural killer (NK), and γδ-T cells. Here, IL17A is linked to endothelial dysfunction.