Psoriasis is a systemic inflammatory disease fundamentally driven by the IL-23/Th17/IL-17 axis. In this pathway, IL-23 from dendritic cells and macrophages promotes Th17 lymphocyte survival, stabilizing the release of proinflammatory cytokines like IL-17A, IL-17F, and IL-22 [3,7-11]. The gene discussed is IL17A; the disease is psoriasis.