Glycosylation is also required for effective TCR and CD28 co-stimulation; thus, its disruption compromises naïve T cell activation and appears to alter CD4+ T cell subset polarization, favoring Th2 differentiation while reducing the development of regulatory T cells and Th17 cells, ultimately leading to elevated serum IgE levels and eosinophilia [7]. This evidence concerns the gene CD4 and Increased total eosinophil count.