At 2.8 W, HIFU induced a relatively low level of LPO in tumor cells, while higher-power HIFU induced an LPO peak at 30 s, after which the proportion of LPO-positive cells either maintained at this level (8.5 and 10.1 W) or gradually declined (11.6 W) (Fig. S2B). This evidence concerns the gene LPO and neoplasm.