SMAD3 and hereditary disease: Genetic disorders cause most TAAD cases, and TAAD-causing mutations have been identified in fibrillin-1, collagen type III alpha 1, transforming growth factor (TGF) B2, TGFB3, TGF-β receptor (TGFBR), α-smooth muscle actin (ACTA2), mothers against decapentaplegic homolog 3 (SMAD3), myosin heavy chain 11 (MYH11), and solute carrier family two member 10.3