TNF and neoplasm: Wang et al.189utilized the dual properties of nano-enzymatic catalysis and magneto-thermal oscillation of platinum-nickel (PtNi) bimetallic “trilobal” nanostructures (PPTNS) to activate caspase-1 and release cytokines, and the levels of TNF-α and IFN-γ were significantly elevated in tumor tissues to effectively induce cellular death in tumor tissues, which resulted in a significant increase of TNF-α and IFN-γ levels in tumor tissues.