A comprehensive workup was conducted, including complete blood count, liver and renal function tests, serum electrolytes, Mantoux test, serum angiotensin-converting enzyme (ACE) levels, vitamin B1, B2, B12 levels, antinuclear antibodies, fundus autofluorescence, erythrocyte sedimentation rate, C-reactive protein, and infectious disease screenings (TPHA, rapid syphilis antibody, HBsAg, HCV, HIV). The gene discussed is ACE; the disease is syphilis.