Other classifications have categorized HCC into immune “high,” “mid,” and “low,” or as “immunocompetent” (normal T cell infiltration), “immunosuppressive” (high CD45, regulatory T and B cells and immunosuppressive macrophages) and “immunodeficient” (reduced infiltration of lymphocytes) based on the infiltration and activity of the immune cells (11, 52, 53). This evidence concerns the gene PTPRC and hepatocellular carcinoma.