Likewise, the rate of proliferating hepatocytes, which were identified as Ki67 and hepatocyte nuclear factor 4 expressing cells, was also observed to be highest in the tumor and IM regions with an average of 0.3 ± 0.2% and 0.3 ± 0.17 to total hepatocyte population (Figure 1G). This evidence concerns the gene MKI67 and neoplasm.