In type IV LN, CD16+ monocytes are found at the sites of capillary immune complex deposition, which is related to the expression of the endothelial cell CX3C chemokine ligand 1 (CX3CL1), which may promote the aggregation of these monocytes, suggesting an important role of monocytes in the pathogenesis of LN (34). The gene discussed is CX3CL1; the disease is lobular neoplasia.