PSMB8 and central nervous system cancer: PSMB8 and 9 are also overexpressed in lung, pancreatic, stomach, colon, prostate, thyroid, liver, uterine, cervical, testicular, ovarian and rectal cancers, as well as in diffuse large B cell lymphoma, acute myeloid leukemia, glioma, glioblastoma, cholangioma and melanoma (45, 68–70).